The session is 4th in a series of highly-reviewed “Debates in Cardiology.” This session debates the practice of conducting genetic testing in unaffected individuals at-risk for cardiogenetic disease due to family history, when testing an affected family member is impossible or impracticable. While this is traditionally avoided in cardiovascular genetics, increasing accessibility of genetic testing and other developments in the field challenge this approach in some cases. With clinical, scientific, ethical, and legal issues to consider, which vary between cardiovascular phenotypes and in pediatric versus adult practice settings, this session presents the pro and dissent stances on this question in an engaging debate-style format.